Overexpression of p53 Gene in Esophageal and Cervical Cancer and the Relationship with Radiotherapy Effects
ZHANG Xiao-zhi
WANG Xiao-li
LI Xu
Abstract：Objective: To investigate the relationship between p53 protein overexpression in esophageal and cervical squamous cell cancer and their clinical radiosensitivity. Methods: The immunohistochemical assays were done for 52 cases with esophageal and cervical squamous cell cancer. The relationship between the assay results and sho rt-terrm radiotherapy was investigated. Results: p53 overexpression was 52. 38 % and 35. 48% respectively, in esophageal cancer and cervical cancer; p53 overexpression in high differentiated squamous cell cancer was lower than those in moderate and poor differentiated cases (P ＜ 0.05). There was no relatwnship between p53 overexpression and stages (P ＞0. 05). In the cases of cervical cancer, p53 overexpression had the less short-term effect(P＜0. 05), and In esophageal cancers, there was no relationship with radiotherapy effect(P＞ 0. 05).Conclusion : This study suggests that p53 gene has the certain relationship with tumor radiosensitivity.
Keywords：esophageal carcinomacervical carcinomap53 generadiosensitivity
Publication Date：2003-09-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 249-253 )