Laminins Expression in Children with Mesangial Proliferative Glomerulonephritis
ZHAO Fei
HUANG Song-ming
CHEN Rong-hua
FEI Li
GUO Mei
HUANG Wen-yan
Abstract：Objective: To investigate the role of laminins in the pathogensis of mesangial proliferative glomeruonephritis (MsPGN) in children. Methods: Eighteen renal biopsy specimens of MsPGN and 6 normal kidneys were stulied by means of immunohistochemistry and in situ hybridization.Results: ① Protein of α1 chain and γ1 chain of laminin increased around the segnents of proliferative mesangium. Increased expression of α2 and β1 proteins was found in the segments uith mesangial proliferation whereas the β2 chain expression decr eased in these areas. ② The mRNA expression of α1, α2, β 1 and γ1 increased to different degrees in glomeruli with mesangial proliferation. But no difference was detected among Mild, Moderate, and Severe MsPGN. Conclusion ; ① The quantitative and qualitative alterations of laminin chains' distribution uere found in the measngial proliferative glomeruli. The proliferative mesangial cells were the origins of abnormal accumulation and expression of laminins. ② These changes may be the basis of the progresses of MsPGN.
Keywords：lamininmesangial proliferative glomeruonephritisimmunohistoche-mistryin situ hybridization
Publication Date：2003-09-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 237-242 )