The Value of CSF Level of β-amyloid Protein in the Diagnosis of Alzheimer's Disease
CHENG Hong
DING Xin-sheng
WANG Kun
ZHANG Xue-ling
WANG Ying
YAO Juan
DENG Xiao-xuan
Abstract：Objective:To evaluate the diagnostic potential of cerebrospinal fluid ( CSF) levels of β-amyloid protein (Aβ) as biochemical marker for senile dementia in clinical practice. Methods: Sensitive enzyme-linked immunosorbent assay ( ELISA) was performed in our laboratory to detect the CSF levels of Aβ1-40, Aβ1-42 in 54 patients with Alzheimer's disease (AD), and 30 normal controls (NC). Results: The cut off value of Aβ ratio and Aβ1-42 concentration in NC group provided 54. 51%, 90. 00% sensitivity and 81. 25%, 84. 38% specificity respectively in diagnosis of AD. Conclusion: AD group bad a significant decreased level of Aβ1-42 and an increased level of Aβ ratio, compared with NC group.
Keywords：Alzheimer's diseasecerebrospinal fluidβ-amyloid protein
Publication Date：2003-05-02
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 106-109 )