A Study on Apolipoprotein E Polymorphism in Early Onset of Coronary Heart Disease
Abstract：Objective:To assess the relationship between apolipoprotein E(apoE) polymor phism and earlyonset of Coronary heart disease ( CHD) and the effect of apoE on lipids and lipoproteins in Chinese healthy sub-jects. Methods:Sixty-eight cases (CHD1) aged less than 55 y, 136 cases (CHD2) aged more than 65y withCHD and 136 healthy subjects were enrolled and their plasma levels of triglyceride ( TG ), total cholesterol (TC) andhigh density lipoprotein cholesterol ( HDL-C) were determined. The apoE genotypes were identified by polyrnerasechain reaction-restriction fragment lengths polymorphism. Results :apoE3/ 4 genotype and E4 allele frequency inCHD1 were higher than those in CHD2 and healthy subjects and no difference was found between CHD2 andhealthy subjects. Meanwhile the plasma levels of TC and low density lipoprotein cholesterol ( LDL-C ) were higher inCHD2 than in either CHD1 or healthy subjects. Each apoE isoprotein has variable TC and LDL-C levels character-ized by E2 (E2/2+ E2/3) ＜E3(E3/3) ＜E4(E4/4+E3/4). Conctusion:apoE is one of the geneticfactors that affect the TC and LDL-C levels and apoE4 may be an independent genetic factor of early onset of CHD.
Keywords：coronary heart diseaseapolipoprotein Epolymorphismearly onset
Publication Date：2003-03-02
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 82-86 )