Association of Glu298Asp Polymorphism of the Endothelial Nitric Oxide Synthase Gene with Essential Hypertension in Elderly People
Abstract：Objective: To investigate the association of Glu298Asp polymorphism of theeNOS gene with essential hypertension in elderly people. Methods:Ninety-five cases of essential hy-pertension were randomly chosen from outpatients and inpatients as the study group, and an equal numberof sexes,age-matched healthy people as the control group. Their height,weight and blood pressure wererecorded and their fasting plasma lipid concentrations were measured. Glu298Asp polymorphism of theeNOS gene was measured using the methods of PCR and RFLP. Results: The constituent ratio of Geno-type Glu/Asp in the study group (26.3%) was higher than that in the control group (12.6% ,x2=5.67,P＜0. 05),the allelic frequency of 298Asp in the study group (13.2%) was significantlyhigher than that in the control group (6. 3% ,x2= 5.06,P＜0.05). Conclusion : Glu298 Aspvariant of the eNOS gene may be an independent predictor in essential hypertension.
Keywords：endothelial nitric oxide synthaseessential hypertensiongene polymor- phism
Publication Date：2003-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 30-34 )