Research progress of oliceridine in perioperative pain management
YUAN Muzhao
MA Haiping
Abstract：Although traditional opioids remain first-line agents,they frequently cause opioid-related adverse events such as respiratory depression and postoperative nausea and vomiting.Oliceridine,a novel biased μ-opioid receptor agonist,preferentially activates the G-protein signaling pathway while down-regulating β-arrestin recruitment;theoretically,this mechanism preserves analgesic efficacy and lowers the incidence of opioid-related adverse events.A growing body of domestic and international studies has demonstrated that oliceridine is safe and effective during general anesthesia induction,patient-controlled postoperative analgesia,and anesthesia outside the operating room.It can partially replace conventional opioids,reduce their consumption,and provide a safer and more effective anesthetic regimen for surgical patients.
Keywords：oliceridinepainbiased receptor agonistopioid-related adverse eventsclinical application
Publication Date：2026-02-15
Online Publishing Date：2026-03-19(First online date of this platform, not the publication date of the document)
Pages：5( 87-91 )