Progress toward the clinical application of esketamine in painless diagnosis and treatment
QIAN Qing
SHI Qinye
ZHAO Di
Abstract：Esketamine,as the S(+)-enantiomer of ketamine,possesses unique pharmacological properties,enabling rapid and effi-cient analgesic and sedative effects through NMDA receptor blockade.In short-duration painless procedures such as gastroscopy,abortion and bronchoscopy,the combined use of esketamine with propofol or remimazolam has optimized anesthesia protocols by reducing the inci-dence of hypoxemia,hypotension,and postoperative adverse reactions,thereby improving patient comfort and recovery quality.Its rapid metabolism significantly shortens postoperative recovery time and enhances operating room efficiency.However,potential impacts during high-dose or long-term use require attention.This article summarizes the pharmacological mechanisms and current clinical applications of esketamine,proposes strategies for personalized use in high-risk patients and highlights its significant advantages and development poten-tial in the field of painless procedures.
Keywords：esketamineanalgesiapainless gastroscopypainless abortionbronchoscopyadverse reactions
Publication Date：2025-06-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 268-271 )