Efficacy of midazolam oral administration combined with lidocaine cream in pedi-atric oral treatment

CHEN Qiong; JIA Liyong; CUI Xiaofan

doi:10.3969/j.issn.2096-2681.2025.02.007

Abstract：Objective To explore the effect of midazolam combined with lidocaine cream in pediatric oral treatment.Methods A total of 100 pediatric dental patients with an average age of(6.93±1.31)years old,32 males,68 females,ASA Ⅰ or Ⅱ,in Dalian Stomato-logical Hospital from September 2022 to September 2024 were selected and randomly divided into local anesthesia group(n=37),low-dose group(n=31)and high-dose group(n=32)according to random number table method.The local anesthesia group received place-bo+lidocaine cream+local anesthesia.The low-dose group was given 0.35 mg/kg midazolam oral solution+lidocaine cream+local anesthesia,and the high-dose group was given 0.5 mg/kg midazolam oral solution+lidocaine cream+local anesthesia.The behavioral scores,sedation-related response indicators,compliance,dental treatment completion rate,incidence of adverse reactions,and postopera-tive satisfaction of the three groups were compared.Results After treatment,compared with local anesthesia group,Frankl compliance scores were higher,behavior scores,MDAS scores,DFS scores and the incidence of adverse reactions(6.26％,3.23％)were lower in high-dose group and low-dose group,with statistically significant difference(P＜0.05).During treatment,compared with local anesthe-sia group,behavioral scores,pharyngeal reflexes and VAS scores were lower,and Frankl compliance scores were higher in high-dose group and low-dose group,with statistical significance(P＜0.05).Conclusion Midazolam oral solution combined with lidocaine cream can effectively reduce dental fear in pediatric patients,reduce sedation-related reactions in children with minor oral surgery,and lower the incidence of adverse reactions in the treatment of low-dose midazolam oral solution with lidocaine cream,and improve the compliance of children receiving dental procedures.