The safety and effectiveness of anesthesia consciousness index in guiding the induction of general anesthesia with ciprofol

REN Dongqing; LI Xia; LI Ting; SHI Lei; LI Ruifeng; YAN Wenjun; ZHU Lei

doi:10.3969/j.issn.2096-2681.2025.01.006

Abstract：Objective To evaluate the safety and effectiveness of anesthesia consciousness index(Ai)in monitoring the induction of general anesthesia with ciprofol.Methods A total of 82 inpatients,aged 18-60 years,BMI 18-30 kg/m2,ASA Ⅰ or Ⅱ,receiving non-cardiac or non-neurosurgical elective surgery under general anesthesia with endotracheal intubation in Gansu Provincial Hospital from October 2023 to January 2024 were randomly divided into propofol group(n=41)and ciprofol group(n=41).During anesthesia induction period,propofol group was given 1.5-2.5 mg/kg propofol,ciprofol group was given 0.4 mg/kg ciprofol,and other anesthesia induction drugs were the same.Safety indicators:(1)changes in mean arterial pressure(MAP)and heart rate(HR)before induction(T0),before endotracheal intubation(T1),1 min after endotracheal intubation(T2),3 min after endotracheal intubation(T3),and 5 min after endotra-cheal intubation(T4);(2)cardiovascular adverse events and complications(body movement,choking,tearing)at T0,T,,T2,T3,T4.Effective indicators:(1)Ai were recorded before anesthesia induction(t0),2 min after anesthesia induction(t1),4 min after anesthesia induction(t2),6 min after anesthesia induction(t3),8 min after anesthesia induction(t4),10 min after anesthesia induction(t5),15 min after anesthesia induction(t6);(2)the rate of successful induction of general anesthesia.Results There was no significant difference in MAP between the two groups at each time point(P＞0.05).There was a statistically significant difference in heart rate at T4 between the two groups(P＜0.05).There were statistically significant differences in systolic hypotension and diastolic hypotension between the two groups at T1(P＜0.05),and there were statistically significant differences in sinus tachycardia between the two groups at T2(P＜0.05).While there was no significant difference in cardiovascular adverse events between the two groups at other time point(P＞0.05).There was significant difference in Ai between the two groups at t1 and t6(P＜0.05).The success rate of anesthesia induc-tion of both groups were 100％.Conclusion Under the guidance of Ai,0.4 mg/kg ciprofol is safe and effective during the induction of general anesthesia.Patients are well tolerated and hemodynamically stable during induction.