Clinical value of dexmedetomidine combined with sufentanil in postoperative anal-gesia for patients undergoing laparoscopic total hysterectomy
YIN Menglan
LIU Danhong
WANG Bei
Abstract：Objective To analyze the clinical value of dexmedetomidine combined with sufentanil in postoperative analgesia for patients undergoding laparoscopic total hysterectomy.Methods A total of 80 patients,aged 40-60 years,ASA Ⅰ or Ⅱ,undergoing laparoscopic total hysterectomy in Changzhou Wujin Hospital of Traditional Chinese Medicine from February 2019 to March 2022 were enrolled.The patients were randomly divided into sufentanil group(n=40)and dexmedetomidine combined with sufentanil group(n=40).The sufentanil group was treated with sufentanil for analgesia after surgery,and the dexmedetomidine combined with sufentanil group was treated with dexmedetomidine combined with sufentanil for analgesia after surgery,and the pain score,sedation score,number of self-controlled analgesic pump compressions,serum cortisol(Cortisol),brain-derived neurotrophic factor(BDNF),interleukin-6(IL-6)and the incidence of adverse reactions were evaluated.Results The numerical rating scales(NRS)at 2 h,6 h,12 h and 24 h postoperatively were 2.98±0.34,2.01±0.22,1.67±0.14 and 1.75±0.16 in the dexmedetomidine combined with sufentanil group,which were lower than those in the sufentanil group(3.59±0.57,2.63±0.34,2.26±0.27,2.19±0.25)(P＜0.05);the Ramsay sedation scores at 2 h,6 h,12 h and 24 h postoperatively were 3.09±0.39,2.16±0.27,1.87±0.18 and 1.81±0.17 in the dexmedetomidine combined with sufentanil group,which were lower than those in the sufentanil group(3.74±0.61,2.68±0.39,2.32±0.29,2.22±0.28)(P＜0.05);the number of PCA compressions at 24 h and 48 h in the dexmedetomidine combined with sufentanil group were 8.96±1.56 and 10.75±1.72,which were lower than those in the sufentanil group(12.34±1.93,18.52±2.13)(P＜0.05);the serological indexes of the dexmedetomidine combined with sufentanil group at 48 h after surgery(Cor:118.47±13.28 μg/L,BDNF:3.72±0.53 µg/L,IL-6:8.41±0.76 ng/L)were lower than those in the sufentanil group(Cor:202.75±16.29,BDNF:4.47±0.75,IL-6:11.92±1.25)(P＜0.05).The incidence of adverse reactions in the dexmedetomidine combined with sufentanil group(5％)was lower than that in the sufentanil group(22.5％)(P＜0.05).Conclusion Dexmedetomidine combined with sufentanil has a high value for analgesia after laparoscopic total hysterectomy,which can provide good analgesic and sedative effects,reduce perioperative stress and inflammation,and reduce postoperative adverse reactions,which is worthy of application.
Keywords：dexmedetomidinesufentanillaparoscopytotal hysterectomy
Publication Date：2024-12-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 313-317 )