The application of the exhaled nitric oxide in ischemia-reperfusion injury during liver transplantation

WANG Dongchun; LI Meng; LIU Desheng; YAN Haiyan; MA Hongyan; AN Da; GUO Lei; LI Enyou

Abstract：Objective To explore the relationship between exhaled nitric oxide(eNO) and ischemia-reperfusion injury during liver transplantation through monitoring eNO.Methods A total number of 10 recipients who underwent liver transplantation received general anesthesia at the First Clinical Medicine Affiliated to Harbin Medical University from September 2015 to February 2017.Exhaled gas and arterial blood samples were collected at predict 10 min before anhepatic stage(T0), predict 10 min before neohepatic stage(T1), the time of hepato-reperfusion(T2), 10 min of neohepatic stage(T3), 20 min of neohepatic stage(T4), 30 min of neohepatic stage(T5) and the end of surgery(T6), their eNO and lactate(Lac) were measured.Results All patients completed surgery successfully.Hemodynamic changed obviously during the operation.From T0 to T6, the level of eNO increased firstly and then decreased.Compared with T0, the level of eNO at T2 was significantly increased and reached the highest value (20.20±5.55 vs 14.40±3.86), T5 returned to the level of T0;From T0 to T6, the level of Lac gradually increased;eNO was not significantly correlated with Lac.Conclusion The eNO of liver transplantation patients is significantly increased in the new liver stage, and then gradually decreased to the stage of anhepatic stage.The mechanism may be related to the aischemia-reperfusion injury of the new liver.eNO may be a new index to predict ischemia-reperfusion injury during liver transplantation.