Immunoregulatory role of regulatory T cells in acute lung injury
WANG Peng
OUYANG Nibing
ZHANG Ranyang
ZHOU Fangliang
GAO Qiang
Abstract：Acute lung injury(ALI)and its critical stage of acute respiratory distress syndrome(ARDS)are common critical illnesses in clinical practice.The pathological process involves complex immune imbalance and tissue repair disorders.Regulatory T cells(Treg)are important regulatory factors in immune regulation that play a crucial protective role in ALI/ARDS through multiple mechanisms such as secreting inhibitory cytokines,blocking the activation of effector T cells,regulating immune cell subsets,and promoting alveolar epithelial repair.Therefore,in-depth exploration of the specific mechanism of Treg in ALI/ARDS will provide important basis for developing targeted immunoregulatory therapeutic strategies.This article reviews the biological characteristics of Treg,its mechanism of action in ALI/ARDS,and related immunotherapy research progress,providing new ideas for targeted immune regulation of ALI/ARDS.
Keywords：acute lung injuryregulatory T cellsinflammatory responseimmune regulationimmunotherapyreview
Publication Date：2026-02-28
Online Publishing Date：2026-03-23(First online date of this platform, not the publication date of the document)
Pages：5( 156-160 )