Investigation on the relationship between CTLA-4 gene polymorphism and breast cancer incidence in female patients with type 2 diabetes mellitus
PAN Shuangshuang
LIU Xiao
ZHANG Lihua
ZHANG Wang
Abstract：Objective To investigate the relationship between cytotoxic T lymphocyte-associated antigen-4(CTLA-4)gene polymorphism and breast cancer in female patients with type 2 diabetes mellitus(T2DM).Methods A total of 337 female T2DM patients admitted from July 2022 to March 2025 were selected as the study subjects,and they all underwent CTLA-4 gene polymorphism testing.They were divided into breast cancer group and non-breast cancer group according to the prevalence of breast cancer in female T2DM patients.The clinical data and CTLA-4 gene polymorphism of the two groups were compared,and the relationship between CTLA-4 gene polymorphism and breast cancer in women with T2DM was analyzed.Results Among 337 female T2DM patients,42 patients had breast cancer and the prevalence rate was 12.46％.The glycosylated hemoglobin(HbAlc),homeostasis model assessment of insulin resistance(HOMA-IR),distribution of the AA genotype at the CTLA-4 gene-49 locus and A allele frequencies in breast cancer group at admission were higher than those in non-breast cancer group(P＜0.05,P＜0.01).Multivariate logistic regression analysis showed that HbAlc,HOMA-IR and the AA genotype and A allele of CTLA-4 gene-49 locus were risk factors for breast cancer in women with T2DM(P＜0.01).Conclusion The AA genotype and A allele of CTLA-4 gene-49 locus are associated with breast cancer in women with T2DM.
Keywords：diabetes mellitustype 2femalebreast tumorcytotoxic T lymphocyte-associated antigen-4genetic polymorphismglycated hemoglobininsulin resistance indexanalysis of influencing factors
Publication Date：2026-02-28
Online Publishing Date：2026-03-23(First online date of this platform, not the publication date of the document)
Pages：5( 139-143 )