Mendelian randomization analysis of circulating white blood cells and juvenile idiopathic arthritis
DU Sijie
ZHANG Guowei
LI Shumin
GUO Ke
YAO Chen
Abstract：Objective To investigate the causal relationship between circulating white blood cells(WBC)and juvenile idiopathic arthritis(JIA)using a two-sample Mendelian randomization(MR)analysis,and to provide a reference for the treatment strategy of JIA.Methods Relevant data of WBC and JIA were extracted from the public data of genome-wide association studies.Then,bidirectional MR analysis was conducted using the inverse variance weighted method(IVW),MR-Egger regression method,mixed contamination method,and Bayesian weighted Mendelian randomization.A series of sensitivity analyses were used to verify the robustness of the results.Results After MR analysis,false discovery rate(FDR)correction and sensitivity verification,calculations using IVW as the main method showed that neutrophils could reduce the risk of JIA(OR=0.752,95%CI:0.622,0.908,P=0.003,PFDR=0.003),and that JIA could lead to increased monocyte counts(bete=0.015,95%CI:0.007,0.022,P=1.90E-04,PFDR=1.14E-03).Conclusion A bidirectional causal association is identified between WBC and the risk of JIA occurrence.
Keywords：juvenile idiopathic arthritiscirculating white blood cellscausal inferenceMendelian randomizationneutrophilsmonocytes
Publication Date：2025-11-28
Online Publishing Date：2025-12-22(First online date of this platform, not the publication date of the document)
Pages：5( 819-823 )