Research advances in neuro-immune mechanisms of chronic pain
YANG Hong
ZHOU Xianli
HOU Jingming
Abstract：Chronic pain impairs functions across multiple dimensions,including physical,psychological,and social well-being.The neuro-immune mechanisms involve complex interactions between the immune system and nerve fibers at one or multiple levels of the peripheral or central nervous system.In recent years,research on the neuro-immune circuit mechanisms underlying the generation,transmission,modulation,and integration of chronic pain has advanced rapidly.However,the overall interactive dynamics of neuro-immune mechanisms remain unclear.This article systematically reviews recent advances in the neuro-immune mechanisms of chronic pain,elucidating the cascading transformation from peripheral to central sensitization.These findings provide a theoretical basis for a deeper understanding of the overall pathophysiological basis of pain chronicity and the exploration of effective clinical strategies.
Keywords：chronic painneuro-immune mechanismsneuroinflammationpain sensitizationpain matrix
Publication Date：2025-09-28
Online Publishing Date：2025-11-20(First online date of this platform, not the publication date of the document)
Pages：10( 679-688 )