Molecular mechanisms and synergistic strategies of combination therapy in breast cancer
SI Jiahao
SHI Jinglu
WEI Zheng
GE Jin
WU Jiajia
YANG Min
LI Zichu
LIN Weiwei
ZHANG Yan
WANG Xueqin
LI Na
DUAN Shaobo
Abstract：Breast cancer is the leading cause of cancer-related mortality among women worldwide and has drawn extensive research attention.Owing to its molecular heterogeneity,drug resistance,and low therapeutic response,single-modality treatments often fail to achieve satisfactory efficacy or broad applicability.Combination therapy,designed based on the pathophysiological characteristics,related signaling pathways,and biomarkers of breast cancer,has emerged as a promising approach for improving therapeutic outcomes.With the advancement of research on combination strategies,the understanding of their molecular mechanisms—particularly key signaling pathways and biomarkers—has become increasingly important.However,comprehensive reviews addressing these molecular mechanisms and synergistic strategies remain scarce.This article summarizes recent advances in combination therapy for breast cancer,providing a comprehensive review of recent combination therapies for breast cancer and their underlying molecular mechanisms,and focusing on key signaling pathways involved in combination therapy and synergistic strategies,thereby providing theoretical insights and reference for researchers,graduate students,and clinicians engaged in the development of novel combination therapeutic strategies for breast cancer and related malignancies.
Keywords：breast neoplasmscombination therapysignaling pathwaysbiomarkersreview
Publication Date：2025-09-28
Online Publishing Date：2025-11-20(First online date of this platform, not the publication date of the document)
Pages：12( 667-678 )