Research progress on the mechanism of macrophages in erectile dysfunction
TANG Tang
ZHAO Yipeng
ZHANG Tao
MA Ziyang
WEI Jintao
WU Zhiyu
ZHANG Peihai
Abstract：Erectile Dysfunction(ED)is a relatively common clinical condition characterized by male sexual dysfunction.Macrophages,as key components of the immune and inflammatory response systems,play crucial roles in immune surveillance,tissue repair,and the maintenance of tissue homeostasis in processes related to erectile function.Immune inflammation is recognized as one of the pathological factors contributing to ED,and inflammatory markers—including macrophages—are widely believed to be closely associated with the onset of the disorder.This review summarizes the multifaceted roles of macrophages in vascular injury,neural repair,hormonal balance,and immune microenvironment remodeling in the context of erection.It aims to provide a theoretical foundation for further investigation into the involvement of macrophages in ED and discusses the potential of macrophage-targeted therapies for treating ED.
Keywords：erectile dysfunctionmacrophagesimmune regulationstem cellsnerve repairhormone balance
Publication Date：2025-07-28
Online Publishing Date：2025-10-28(First online date of this platform, not the publication date of the document)
Pages：10( 519-528 )