Research progress of WD repeat and FYVE domain-containing protein 1(WDFY1)
ZHU Xiaoqing
LI Siqi
TIAN Cheng
HE Rui
FEI Lei
CHEN Yongwen
HUANG Xiaoyong
Abstract：WDFY1 is a member of the protein family containing the WD repeat and FYVE structural domains,acting as a junction that assists the recruitment of downstream molecules by Toll-like receptor 3/4(TLR3/TLR4)and promotes the body's natural anti-viral and anti-bacterial immune response.In recent years,the role of WDFY1 has been successively reported in various disease models,such as neurological diseases,autophagy and tumors.This paper aims to provide a comprehensive review of the current state of WDFY1 research,encompassing its expression distribution,cell biological function and its role in disease development,and take a prospect on the potential of WDFY1 as a target in rheumatoid arthritis.
Keywords：WDFY1Innate immuneNeurological diseasesAutophagy and tumorsRheumatoid arthritis
Publication Date：2025-04-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 279-284 )