Roles of Nrf2 in inflammatory bowel disease-associated inflammatory-cancer transition
WU Nan
HU Yisen
WANG Haiqiang
Abstract：Inflammatory bowel disease(IBD)is a chronic nonspecific inflammatory disease of the intestines,mainly including Crohn's disease(CD)and ulcerative colitis(UC).More than 20％of IBD patients progress to colitis-associated colorectal cancer(CAC)through the inflammation-cancer sequence within 30 years of disease onset.Nuclear transcription factor E2-related factor 2(Nrf2)is a transcription factor closely related to IBD and CAC,which not only affects inflammation but also plays a significant role in regulating the"Inflammation-cancer transformation".In this paper,we review the studies on the mechanism of Nrf2 in the"Inflammation-cancer transformation",focusing on the mechanism and dual roles of Nrf2 in oxidative stress,inflammatory factors,immune response,metabolic reprogramming and gene expression,with an aim of providing a reference for further understanding the potential value of its intervention in the human tumor process.
Keywords：Nrf2Inflammation-cancer transformationInflammatory bowel diseaseOxidative stress
Publication Date：2025-01-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 52-58 )