Research progress on the role of IFN-β in viral infection
SHAO Shuai
JI Xiaolan
FAN Yiyang
BAI Jialin
LI Qiongyi
Abstract：IFN-β,secreted by fibroblasts,leukocytes,epithelial cells and other cells,plays an important role in the intrinsic immune response,and involves in the body's anti-viral immune response by inducing a variety of antiviral genes.It has various biological functions such as inhibiting viral replication,anti-parasite,influencing cell proliferation,participating in immune regulation,and anti-tumor.This paper mainly reviews the activation of IFN-β and its antiviral effects after DNA virus and RNA virus infections and the immune escape mechanism evolved by some viruses,and summarizes the progress of the research on the interferon signaling pathway regulated by viral infections,so as to provide references for the future research on the mechanism of antiviral infections and their prevention and treatment.
Keywords：InterferonIFN-βAntiviralInfection
Publication Date：2024-11-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：12( 844-855 )