Research progress of DPP-4 in inflammatory bowel disease
WANG Yiran
HE Zixuan
FAN Ruyu
ZHOU Shijin
YE Xuanxuan
WU Cong
Abstract：The fundamental pathogenic mechanisms of inflammatory bowel disease(IBD),a chronic inflammatory illness affecting the gastrointestinal tract,are still not fully understood.Dipeptidyl peptidase Ⅳ(DPP-4)is a glycoprotein found on the cell surface that has signaling and enzymatic properties.In addition,there is growing evidence from animal models and clinical trials that DPP-4 inhibitors have potential impacts beyond only lowering blood sugar levels,such as immunomodulatory and anti-inflammatory capabilities.This article reviews the biological properties of DPP-4 and its research progress in the diagnosis and treatment of IBD.It also discusses the mechanism of DPP-4 in IBD,aiming to provide a more in-depth understanding of the role of DPP-4 in IBD.
Keywords：Inflammatory bowel diseaseDipeptidyl peptidase ⅣDPP-4 inhibitorImmunoregulation
Publication Date：2024-04-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 399-404 )