Research progress of nano-delivery technology for the development of vaccines against Helicobacter pylori
SONG Zijuan
ZHANG Yuandong
Abstract：Helicobacter pylori(H.pylori)infection is closely related to the occurrence of a series of gastrointestinal diseases.Antibiotic resistance in the current H.pylori treatment has greatly increased the recurrence rate of the infection,making its eradication difficult.Vaccine is one of the most effective strategies to prevent and control bacterial infectious diseases,however,there is still no anti-H.pylori vaccine on the market.The use of nanotechnology to improve vaccine stability and efficacy has shown promising results in laboratory studies.This paper summarizes the current status of anti-H.pylori vaccine development,and reviews and discusses the research progress of H.pylori vaccine based on nano-delivery systems,including mucus-inert nanoparticles,acid-resistant nanoparticles,and outer-membrane vesicles etc.,with the aim of providing a reference for the subsequent development of an effective and safe H.pylori vaccine.
Keywords：Helicobacter pyloriCandidate antigenVaccineNanotechnology
Publication Date：2024-04-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 393-398 )