The progress and challenges of neoantigen-based cancer vaccines
WU Ming
XING Xiaofang
YAO Gang
Abstract：Personalized neoantigen vaccines,a cutting-edge technology in cancer immunotherapy,have garnered significant attention in recent years.Neoantigens are unique antigens produced by tumor-specific mutations,capable of being recognized by the immune system and eliciting a specific anti-tumor immune response.This review summarizes the current state of research on neoantigen vaccines,including the mechanisms of neoantigen generation and relatively screening methods,vaccine design and production,preclinical and clinical research progress,as well as the current challenges and future development trends.We present the potential of neoantigen vaccines in personalized treatment and their significant role in improving the survival rates and quality of life of cancer patients.Additionally,this review highlights the key issues in current research and proposes potential solutions,providing a reference for future studies.
Keywords：NeoantigenCancer vaccineCancer immunologyPersonalized treatment
Publication Date：2024-02-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：11( 195-205 )