Progresses of phage display technology application in fully human antibody discovery
LIU Bixia
LIU Yuan
XIE Jing
GUO Zhengbin
WANG Bin
ZUO Qianfei
ZHANG Rui
Abstract：Phage antibody display technology is currently the most widely used in vitro antibody screening technology,which uses bacteriophages as a vector,and inserts exogenous antibody library genes into phage capsid protein genes,and expresses the capsid protein on the phage surface while also displays the antibody protein.Antibody drugs play an important role in tumor immunity and microbial immunity due to their targeting advantages,which is also an important driving force for them to become a hot spot in the field of pharmaceutical research and development.Therefore,this article reviews the background,basic principles,antibody library types and antibody fragment types of phage display technology,and looks forward to the latest progress and application prospects of fully human antibodies.
Keywords：Phage antibody display technologyFully humanized antibodiesAntibody libraryAntibody screening
Publication Date：2023-10-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 910-915 )