Effects of anti-rheumatic therapy on dyslipidemia in children with juvenile idiopathic arthritis
MO Miaojun
LU Meiping
XU Yiping
ZOU Lixia
ZHENG Qi
Abstract：To investigate the effect of anti-rheumatic drugs on dyslipidemia in children with juvenile idiopathic arthritis (JIA), total of 28 children patients diagnosed as JIA and never been treated with corticosteroids and DMARDs were selected, and then blood lipid level (TG, TC, HDL-C, and LDL-C), inflammatory markers of blood sedimentation (hsCRP and ESR), inflammatory cytokines (IL-1, IL-4, IL-6, IL-10, TNF-α, and INF-γ) in peripheral blood was detected and compared before and 3 months after treatment. The disease activity was measured by using JADAS27. Data showed that the rate of children patients with dyslipidemia was significantly decreased, the levels of TG and LDL-C were significantly decreased, the level of HDL-C was significantly increased, but the levelof TC showed no significant differences after treatment.Furthermore, the levels of hsCRP, ESR, JADAS27, IL-6 were all significantly decreased, while the levels of IL-10, TNF-α and INF-γ showed no significantdifferences. Taken together, anti-rheumatic drugs could improve dyslipidemia in children with JIA, thereby reducing the risk of cardiovascular disease.
Keywords：Juvenile idiopathic arthritisAnti-rheumatic drugsDyslipidemia
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 422-427 )