Cyclophilin A and cell signaling
ZHANG Lihong
YING Demei
NING Linhong
HE Haiyang
Abstract：Cyclophilin A (CyPA) is a widely expressed peptidyl-prolyl cis-trans isomerase with structural and functional conservatism. CyPA can catalyze the cis-trans formation of proline residues in proteins to regulate protein folding and spatial conformation. CyPA was originally discovered as a binding target for the immunosuppressive durg cyclosporine A (CsA), suggesting that CyPA may play an important role in cell signaling. Since then, more and more studies have found that CyPA can mediate the transmission of intracellular signals; while the excellular CyPA can also bind to its cell membrane receptor CD147 to promote intracellular signal production. Through the regulation of cellular signals, CyPA exerts many important biological functions in diseases. This review mainly introduces the important advances of CyPA in cell signaling in recent years, and provides new ideas for better understanding and further research on the important role of CyPA in diseases..
Keywords：CyPACD147Cell signaling
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 823-828 )