Genetic risk of TNFSF4 polymorphisms in children with asthma and allergic rhinitis in Chinese Han population
ZOU Qiyuan
SHEN Yang
KE Xia
PANG Ying
LI Jia
HONG Suling
KANG Houyong
Abstract：Recently, single-nucleotide polymorphisms (SNPs) in the TNFSF4 gene have been shown to be associated with various immune-related disorders. Our aim was to determine whether TNFSF4 polymorphisms confer genetic susceptibility to asthma and allergic rhinitis (AR) in Chinese Han population. We performed a case-control study of 320 asthmatic children and 240 healthy controls. Six SNPs in the TNFSF4 region (rs1234313, rs1234314, rs1234315, rs12039904, rs844648 and rs10912580) were detected by polymerase chain reaction restriction fragment length polymorphism (RFLP). Data showed that 3 SNPs in TNFSF4 (rs1234313, rs1234314 and rs1234315) were significantly correlated with asthma and AR in Chinese Han population. So the result supports that the SNPs in TNFSF4 may be involved in asthma and AR gene risk in the Han Chinese cohort.
Keywords：Allergic rhinitisAsthmaHeredityTNFSF4Single-nucleotide polymorphisms
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 547-552 )