The local immune regulation of shen-ling-bai-zhu powder in traditional Chinese medicine spleen deficiency diarrhea model
SHI Yang
YU Hongyu
Abstract：This study was designed to investigate the local immune regulation of shen-ling-bai-zhu powder in traditional Chinese medicine"spleen deficiency diarrhea"mice. Total of 40 SPF Kunming mice were randomly divided into four groups: group A (control group), group B (model group), group C (shen-ling-bai-zhu powder group) and group D (positive control). Then the spleen and thymus indexes were calculated, the pathological changes of intestinal mucosa were checked by light microscope, and the serum levels of IL-2, IL-12, TNF-α and s Ig A were detected by ELISA. Data showed that in the model group, the spleen and thymus indexes were significantly reduced (P<0. 05), the intestinal epithelial mucosa and villus damaged significantly, and the levels of IL-2, IL-12, TNF-α and s Ig A were markedly downregulated, while all indicators above in Shen-ling-bai-zhu powder group were significantly recovered. These results suggests that Shen-ling-bai-zhu powder significantly increases spleen and thymus indexes in mice with spleen-deficiency diarrhea, and upregulates the levels of serum IL-2, IL-12, TNF-α and s Ig A in intestinal tissue. So the powder improves the immune function and repairs the intestine mucosal injury of "spleen deficiency diarrhea" mice.
Keywords：Shen-ling-bai-zhupowderSpleen deficiency diarrheaSpleen deficiency modelLocal intestinal immune
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 519-523 )