Mutation analysis in a Chinese pedigree with recurrent HSV 1
LIU Wenying
SHEN Zhu
WANG Li
Abstract：This study was performed to detect the gene mutation of a Chinese pedigree with recurrent Herpes.DNA was extracted from the peripheral blood of the herpes recurrent family.Exome sequencing was carried out by Hiseq 2500,and the information was analyzed by using NCBI (HG38) and bioinformatics tools.Data showed that there were a number of genes mutated,in which,USPL1 may be one of the target gene contributed to the recurrent of herpes simplex virus 1 (HSV-1).The mutation of USPL1 was identified in the patients of the family,but not found in other members without HSV-1 recurrence.We speculate that the USPL1 gene may be involved in the recurrence of herpes by the SUMOylation of STAT1.This study provides new candidate genes and ideas for the study of mechanism of HSV-1 recurrence.
Keywords：HSV-1GeneMutationUSPL1
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 273-276 )