Effects of glutamine supplement on HLA-DR expression and efficacy in sepsis patients treated by CVVH

YU Qiuping; YANG Huiwen; YE Xingwen; LUO Yang; LIU Song; ZHAO Xin

doi:10.13431/j.cnki.immunol.j.20180024

Abstract：This study was performed to discuss the effects of glutamine supplementation on the cellular immune function and clinical efficacy in CVVH-treated sepsis patients.Total of 56 cases of sepsis cases complicating acute renal insufficiency were recruited from critical care medicine department of our hospital from January 2016 to June 2017,and randomly divided into glutamine group (n=30) and conventional group (n=26).The patients in glutamine group were given alanylglutamine 10 g/bid via intravenous injection for continuous 3 days after CVVH.The serum albumin (ALB),prealbumin (PA) and calcitonin (PCT) levels were detected before and after treatment in the two groups of patients;the HLA-DR level in the peripheral blood monocytes and APACHEII score of the two groups were detected before and after treatment.Data showed that the levels of albumin and prealbumin in glutamine group were significantly higher than that in conventional group after treatment (P＜0.01);the PCT level of glutamine group was significantly lower than that of the conventional group (P＜0.01);the HLA-DR level of monocytes in glutamine group after treatment was significantly higher than that of the conventional group (P＜0.01).After treatment,the APACHEII score of glutamine group was lower than that of the conventional group (P＜0.01).Thus,we concluded that negative nitrogen balance is involved in CVVH treatment process of sepsis,and suitable glutamine supplementation can improve the nutritional status of sepsis patients by improving cellular immune function.