HIV infection and pyroptosis
CHEN Min
ZHENG Yongtang
Abstract：AIDS is considered to be a chronic disease,inflammation and immune activation in which played an important role.Pyroptosis is the most important mechanism to account for the CD4 + T cells depletion after HIV infection accompanied by releasing inflammatory factors and cell contents.Pyroptosis link the two pathogenic signatures of HIV infection through a common mechanistic pathway:the death of CD4 T cell and chronic inflammation.Therefore,inhibition of pyroptosis may be important for the treatment of HIV/AIDS patients.This paper reviews the molecular mechanism and pathological events of pyroptosis during HIV infection to provide clues of new treatment strategies for AIDS patients.
Keywords：HIV infectionAcquired immune deficiency syndromePyroptosisApoptosisCaspase activation
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 80-85 )