Current status and future prospect of tumor antigen specific T cell receptor engineered T cells therapy
NING Xin
YIN Yanhui
Abstract：Recently,tumor immunotherapy has made inspiring therapeutic effects in clinical practices,which brings new hope for the cure of tumor.T cell receptor engineered T cells (TCR-T) therapy is a novel anti-tumor strategy in which patients' T cells are modified with tumor antigen specific TCR,expanded in vitro,and then re-infused back into the patients to eradicate tumor cells.Several clinical trials have demonstrated the feasibility and potential of this strategy.With the gene sequencing and gene editing technologies advancing rapidly,TCR-T therapy also comes a long way in tumor treatment.This review will focus on the current status,recent progress,clinical trials,challenges and future prospect of TCR-T therapy.
Keywords：Tumor antigenT cell receptor engineered T cellsImmunotherapy
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 65-72 )