Up-regulated expression of IL-18 and IL-18 receptor in eosinophils from allergic purpura patients
ZOU Shanshan
YANG Ruiming
HE Shaoheng
ZHANG Huiyun
Abstract：To investigate the expression of IL-18,IL-18 receptor (IL-18R) and IL-18 binding protein (IL-18BP) in eosinophils from allergic purpura patients and the correlation among them,blood samples were collected from patients with allergic purpura and healthy controls (HCs),then incubated with extracts of Artemisia pollen,dust mite and Platanus pollen,respectively.The expression of IL-18,IL-18BP and IL-18R in blood eosinophils were detected by flow cytometry,while the correlations amonge them were analyzed by SPSS.Data showed that the expression of IL-18 and IL-18R in eosinophils from allergic purpura patients were respectively elevated up to 1.83-fold (P=0.048) and 1.12-fold (P=0.025),compared with HCs;IL-18+ and IL-18R+ eosinophils in patients with allergic purpura were correlated moderately (Pearson correlation coefficient r=-0.559,P=0.000).In addition the mean fluorescence intensity (MFI) of IL-18BP+ eosinophil was down-regulated by 30％ (P=0.005),while the extract of Platanus pollen up-regulated the MFI of IL-18 by 37％ (P=0.027) in eosinophils of allergic purpura patients.In conclusion,the increased expression of IL-18 and IL-18R,and the decreased expression of IL-18BP in eosinophils of allergic purpura patients may suggest that IL-18,IL-18BP and IL-18R are involved in the pathogenesis of allergic purpura.
Keywords：Allergic purpuraEosinophilIL-18IL-18RIL-18BP
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1034-1039 )