The expression of TIGIT and CD155 on CD4+T cells in HIV infected individuals

YIN Xiaowan; LIU Tingting; ZHANG Zining; DING Haibo; FU Shuai; ZHAO Wen; TANG Tian; WANG Xiaonan; JIANG Yongjun

doi:10.13431/j.cnki.immunol.j.20170172

Abstract：To understand the expression of TIGIT receptor and related ligand CD155 on CD4 +T cells in untreated HIV infection individuals,we collected peripheral bloods from 20 healthy human (NC group) and 24 untreated HIV infection individuals (HIV group).The expression levels of TIGIT and CD155 were analyzed by flow cytometry.Data showed that the percentage of TIGIT on CD4+T cells in HIV group was significantly higher than that in NC group (P＜0.000 1),and the expression of TIGIT on CD4+T cells was negatively correlated with the absolute number of CD4+T cells (r=-0.444 1,P=0.029 7).In addition,the TIGIT receptors expressed on CD4+T cells in CD4low group (CD4+T cell counts ≤ 350 cells/μl) was significantly higher than that in CD4hish group (CD4+T cell counts ＞350 cells/μl) in HIV group (P=0.029 2);the TIGIT receptors expressed on CD4+T cells in low viral load group (HIV viral load ≤ 105 copies/ml) was significantly lower compared with high viral load group (HIV viral load ＞105 copies/ml) in HIV group (P=0.015 5).Moreover,the expression of CD155 on CD4+T cells was significantly increased in HIV group compared with NC group (P=0.0042),and the expression of CD155 on CD4 +T cells was positively correlated with the viral load (r=0.4677,P=0.021 2).In addition,the expression of CD155 on CD4+T cells in low viral load group (HIV viral load ≤ 105 copies/ml) was significantly lower compared with high viral load group (HIV viral load ＞105 copies/ml) in HIV group (P＜0.000 1).In conclusion,the percentage of TIGIT and CD155 on CD4+T cells in HIV infected individuals are significantly increased and correlated with the absolute number of CD4+ T cells and the viral load,which may provide an important scientific basis for the treatment and prognosis of HIV.