Empirical study on the therapeutic effect of astragalus polysaccharides in a mouse model of ulcerative colitis
XI Qinhua
LI Yueqin
DAI Juan
ZHANG Guangbo
CHEN Weichang
Abstract：This study was performed to study the effects of astragalus polysaccharides (APS) in the treatment of ulcerative colitis (UC),and to explore whether MDSC involve in this process.UC model was established by DSS inducement in mouse.Then the effects of APS on UC was evaluate at the levels of cytology and molecular biology:exploring the influence of APS on MDSC by analyzing the levels of MDSC before and after the treatment of APS;evaluating the therapeutic effects of APS on UC by pathologic histology.Data showed that the levels of MDSC in bone marrow,spleen,peripheral blood of UC mice were significantly decreased after intervention with APS,indicating APS inhibited the level of MDSC significantly.After depletion bone marrow cells in mice,we further found that the therapeutic effects of APS in MDSC-group was significantly reduced compared with MDSC+ group.In conclusion,APS has a potential application in the treatment of ulcerative colitis,and is dependent or partially dependent on MDSC to achieve this effects.
Keywords：Astragalus polysaccharidesUlcerative colitisMouse modelMDSC
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 975-978,1008 )