The role of IL-2 and IL-2 recepter in autoimmune diseases and organ transplant
HUANG Yiting
ZHANG Mei
Abstract：IL-2 is one of the earliest cytokines discovered and applied in clinical medicine.At the first time,IL-2 drew much attention because of its ability to stimulate the proliferation of T cells.Posterior studies revealed that IL-2 can shift the balance between Tregs and Teffs by activating downstream signaling through the combination with receptor IL-2R.The shifted balance of Tregs and Teffs could maintain the immune tolerance and thus change the course of immune-mediated diseases.Recently,with further research on biological activity of IL-2,scientists re-evaluate the indications,application dose,security,as well as immunotherapeutic effect of IL-2.
Keywords：IL-2Regulatory T cellAutoimmunityTransplantation immunology
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 911-915 )