Upregulated CD95 on CD4+ T cells is positively correlated with activation in CHB patients
LIU Xian
LENG Jin
WANG Dengrong
PENG Lishan
YANG Yang
YI Jixing
XIAO Jian
Abstract：To investigate the relationship between the activation and exhaustion of CD4 + T cells in HBV patients by detecting the expression levels of CD95,CD38,HLA-DR,blood samples were collected from 60 patients with HBV and 16 healthy controls,and the levels of CD95,CD38,HLA-DR were detected by the method of flow cytometry.Data showed that the levels of CD95 +,HLA-DR+,and CD95 + CD38 + CD4 +T cells were increased significantly in HBV patients,compared with healthy controls (P＜0.05).And the expression level of CD95 was positively correlated with HLA-DR (P＜0.01),while negatively correlated with CD38 expression (P＜0.05).All the result indicated that the expression of CD95 plays a pivotal role on the exhaustion of CD4+ T cells;and the depletion of CD4+ T cells may relate to activation-induced cell death.
Keywords：HBVCD4+T cellsCD95CD38HLA-DR
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 879-884,890 )