Research progress of Toll like receptor 8 agonists in immunotherapy
ZHAO Xiaoqing
LENG Jing
Abstract：Small molecule Toll-like receptor 8 agonists mainly including natural nucleoside compounds and synthetic compounds,can effectively activate the innate immune and adaptive immune response resulting in effective anti-infection,anti-tumor response and plays a unique role in neonatal immune.Thus these agonists can be used as excellent adjuvants and independent regents in immunotherapy for various diseases.This review will highlight the preclinical and clinical studies that indicate promise for TLR8 ligands as vaccine adjuvants and independent immunotherapy thus far,then provide a reference for TLR8 as targets for immunotherapy such as infection,autoimmune disease and tumor treatment.
Keywords：TLR8 agonistsImmunotherapyAdjuvants
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 813-818 )