The agonists of Toll-like receptors in tumor immunotherapy
LI Shinan
SHEN Xiaokun
Abstract：Toll like receptors (TLR) are a class of innate pattern recognition receptors,which are widely expressed in human and mouse,including a series of receptors such as TLR1-TLR10.The activation of TLR ligands can activate the downstream signaling pathway and promote the release of a variety of bioactive factors.Recent studies showed that TLR ligands can be used as adjuvants or immune activators for the treatment of tumors.However,there are also several ligands promoting tumor progression.This paper will review the role of different TLR ligands in tumor therapy.
Keywords：ImmunotherapyTLR agonistTumor
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 807-812 )