Research progress of Wnt signaling pathway in regulating immune response
LI Siyu
HAN Qiuju
ZHANG Jian
Abstract：Wnt is a class of secretory glycoproteins working in autocrine or paracrine manner.Wnt family is a group of highly conserved signaling molecules that regulate intercellular signaling during embryonic development.Wnt signaling pathways are classified as β-catenin-dependent canonical pathway and noncanonical pathway,which are widely involved in the proliferation,migration and differentiation of cells.It is noteworthy that Wnt signaling pathways regulate the differentiation and development of immune ceils such as macrophages,T cells and B ceils,as well as the immune response through a variety of mechanisms.In addition,Wnt signaling pathways play important roles in regulating the biological functions of hepatic stellate cells and endothelial cells.Here,we reviewed the progress of Wnt signaling pathways in regulating immune responses.
Keywords：Wnt canonical signaling pathwayWnt noncanonical signaling pathwayImmune cell
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 723-728 )