The function of IL-22 in diseases
ZHANG Yi
LI Xiaoying
SHI Leifeng
Abstract：Interleukins are considered as one of the most important regulators of innate and adaptive immunity-related diseases.Since the discovery in 2000,it has been indicated IL-22 plays a key role in epithelial cells of numerous tissues.IL-22 can be secreted by several kinds of immune cell subsets,and primarily targets non-hematopoietic epithelial and stromal cells.IL-22 can promote tissue proliferation and regeneration,and also regulate host mucosal barrier defense.However,IL-22 also makes the contribution of the pathologic tissue inflammation.Recent studies have demonstrated that IL-22 is a key component in a number of diseases including infection,autoimmune disease and tumor.In this review,we will summarize the functions and mechanisms of IL-22 in these diseases and discuss the potential treatment targeting IL-22 in human diseases.
Keywords：Interleukin-22InfectionAutoimmune diseaseTumor
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 711-716 )