The expression of Mda-7/IL-24 and C-myb and their correlation in Burkitt lymphoma
MA Ming
WEI Sisi
WU Yipeng
YANG Xingxiao
ZHAO Lianmei
WANG Xuexiao
ZHANG Cong
LIU Lihua
SHAN Bao'en
Abstract：This study is aimed to investigate the expression of Mda-7/IL-24 and C-myb expression in the human Burkitt lymphoma tissues and their relationship and clinical significance.The expression of Mda-7/IL-24 and C-myb in 65 cases of Burkitt lymphoma and 33 cases of normal lymphonodus tissues were assayed by immunohistochemistry and Western blotting.The relationship of Mda-7/IL-24 and C-myb expression with age,sex,clinical stage,bone marrow infiltration,Ecog scores,IPI index and survival were analyzed,and survival curve was made.Data showed that the expression of Mda-7/IL-24 was higher,whereas the the expression of C-myb was lower,as compared with normal lymphonodus tissues.The expression of Mda-7/IL-24 was neglatively correlated with C-myb (r=-0.474 9).Low expression of Mda-7/IL-24 or high expression of C-myb was positively correlated with Ki67 scores,malignant grade,bone morrow metastases,IPI scores and shorter survival period.In summary,there is a negative correlation between Mda-7/IL-24 and C-myb expression in Burkitt lymphoma tissues.The low expression of Mda-7/IL-24 and high expression of C-myb could be predictors for worse clinical condition and prognosis of Burkitt lymphoma.
Keywords：Mda-7/IL-24C-mybBurkitt lymphoma
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 691-696 )