Progress in molecular mechanism of Mycoplasma penumoniae-induced inflammation

doi:10.13431/j.cnki.immunol.j.20170114

Abstract：Mycoplasma pneumonia,a major pathogen of community-acquired pneumonias in human,occasionally cause diseases in infants and geriatrics.The pathogenicity and pathogenic mechanism of Mycoplasma pneumonia are not clear so far.Studies have shown that the inflammatory response induced by Mycoplasma pneumonia is the main mechanism of the occurrence of mycoplasma pneumonia,and its pathogenesis mainly includes three aspects:1) Mycoplasma pneumonia membrane lipoprotein recognized by TLR2 can activate the innate immune system through a series of signal transduction pathways,ultimately induces the production of various of proinflammatory cytokines and inflammatory mediators generated by monocytes,macrophages,and natural killer cells;2) Mycoplasma pneumonia elicits macrophage autophagy via interaction with TLR4 after its adherence to host cells,and eventually leading to the secretion of proinflammatory cytokines;3) CARDS toxin of Mycoplasma pneumonia can raise the inflammasome and promote the secretion of IL-1β.Hence,illumination of the pathogenic mechanism of Mycoplasma pneumonia is great helpful to the development of alternative therapeutic or preventive drug targets.