Research progress of TNFSF14/LIGHT in asthma
LI Binbin
SHI Fei
Abstract：TNFSF14/LIGHT,a new member of the tumor necrosis factor (TNF) super family,is mainly expressed on activated T cells,immature dendritic cells,and NK cells.LIGHT can regulate the function of immune system through binding with herpesvirus entry mediator (HVEM) and lymphotoxin β receptor (LTβR).Abundant studies revealed that LIGHT and its signal pathway participates in many aspects of pathological processes in asthma,such as chronic airway inflammation,airway remodeling,airway hyper responsiveness,and pulmonary fibrosis.Therefore,LIGHT may provide new ideas and methods for the prevention and treatment of asthma.Here the complicate roles of LIGHT involved in pathological process of asthma are summarized.
Keywords：LIGHTAsthmaAirway remodelingPulmonary fibrosisChronic airway inflammationAirway hyper responsiveness
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 629-633 )