The expression of programmed death ligand-1 on neutrophils in rheumatoid arthritis patients and its clinical significance
HUANG Zikun
LI Xue
LUO Zhongqin
LUO Qing
Abstract：To investigate the expression of programmed death ligand-1 (PD-L1) on neutrophils from the patients with rheumatoid arthritis (RA) and analyze the clinical relevance to disease severity,the expression of PD-L1 on neutrophils from 54 RA patients and 52 healthy controls (HC) were examined by the technique of flow cytometry.The percentage of PD-L1 + neutrophils was compared between RA patients and HC,and also between inactive and active RA patients.Moreover,the correlation of PD-L1 + neutrophils with laboratory inspection was analyzed.Data showed that the percentage of PD-L1+ neutrophils from RA patients elevated significantly,as compared with HC (P=0.000 1),and the percentage of PD-L1 + neutrophils from active RA patients was significant higher than that of inactive ones (P=0.045 8).The percentages of PD-L1+ neutrophils in RA patients were positively associated with DAS28 (r2=0.081,P=0.037 2),CRP (r2=0.12,P=0.014 9) and ESR (r2=0.14,P=0.007 2).The frequency of PD-L1 + neutrophils in patients with RA was increased significantly in subjects with positive RF (P=0.006 9).Furthermore,the expression of ROS on PD-L1 + neutrophils was significantly increased compared to PD-L1+ neutrophils in RA patients.In conclusion,the aberration percentages of PD-L1+ neutrophil are observed in patients with RA,which correlate with disease activity and the production of antibody.
Keywords：Rheumatoid arthritisNeutrophilPD-L1
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 586-590 )