Research progress on Caspase-11-dependent noncanonical inflammasome in sepsis
XU Mengda
DENG Xiaoming
Abstract：Sepsis,referring to organ dysfunction resulted from improper immune response caused by severe systemic infection,become a major cause of death in ICU.Recently,researches focusing on the immune mechanism of sepsis revealed the vital role of macrophage,as a major source of pro-inflammation cytokine such as IL-1β,IL-6 and TNF-α in sepsis.However,the caspase-11-dependent noncanonical inflammasome pathway has been proved to be a key method that helps macrophage sense various pathogen and play key roles in promoting pro-inflammation cytokines release,pyroptosis and bacterial clearance.This review proposes to light the new sight of the role that caspase-11-dependent noncanonical inflammasome plays in sepsis.
Keywords：SepsisNoncanonical inflammasomePyroptosis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 542-546,552 )