Clinical analysis of chronic periaortitis and the clinical significance of chenodeoxycholic acid in the pathogenesis of chronic periaortitis
CAO Shan
LIN Zhen
SHEN Lichong
FAN Chaofan
GUO Ruru
XU Mingming
JIANG Lindi
BAO Chunde
LYU Liangjing
CHEN Xiaoxiang
Abstract：Chronic periaortitis (CP) is a rare autoimmune disease and serum IL-6 level was found significantly elevated in active CP patients.This study was undertaken to investigate the clinical characteristics of CP and preliminarily explore the role of chenodeoxycholic acid (CDCA) in the pathogenesis of the disease.The clinical data of 17 CP patients,diagnosed from October 2004 to March 2017,were analyzed retrospectively.Serum CDCA levels of 5 CP patients and controls were detected by ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method.The pathological specimen obtained by retroperitoneal puncture from 1 CP patient was stained by immunohistochemistry to detect the expression of IL-6,surface-specific marker of macrophage F4/80 and farnesoid-X-receptor (FXR).As to 17 CP patients,male:female is 3.25:1 and the average age of onset is 62.5+8.4 years.Primary symptoms included abdominal pain,flank and back pain and so on.ESR and CRP could also be elevated.Compared with each control group,serum CDCA levels were significantly reduced in CP patients.Immunohistochemical results showed that IL-6 was highly expressed in the aggregation sites of foam-like cells and lymphocytes within the adipose tissues and collagen fibers.F4/80 and FXR were also expressed.In conclusion,reduced CDCA expression in serum may be a new clinical index of this disease and CDCA-FXR/IL-6 pathway may play a role in the pathogenesis of CP.
Keywords：Chenodeoxycholic acidFarnesoid-X-ReceptorIL-6
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 525-529 )