Correlation between Th1/Th2 cytokines levels and sex hormones levels in PCOS dysgenesis patients
ZHONG Xingming
MIAO Zhulin
CUI Rong
YANG Ning
WANG Xiaolan
WEI Xiangcai
Abstract：This study was performed to explore the association between Th1/Th2 cytokines levels and sex hormones levels in polycystic ovary syndrome (PCOS) dysgenesis patients.Total of 105 cases of dysgenesis patients accepting treatment in our hospital during March 2013 to December 2014 were recruited as the observation cases and 75 cases of nonpregnant normal women were selected as control group.Then hormones and peripheral blood Thl (IFN-γ)/Th2 (IL-4) cytokines were measured with flow cytometry in the menstrual cycle line 2-4 days.Data showed that Th1 cytokine (IFN-γ) proportion in PCOS group was significantly higher than that in control group (24.54±9.38 and 14.64±7.33,P＜0.05);Th2 cytokine (IL-4) in PCOS group and control group was not significant difference (1.44±1.53 and 1.23±1.26,P＞0.05);Th1/Th2 proportion was significantly higher in PCOS group than that in control group (44.21±49.91 vs 20.44±18.15,P＜0.05).In control group,the correlation between Th1/Th2 and FSH was statistical significance (r=0.534;P＜0.000 1);while in PCOS group,significant correlation between Th1/Th2 and testosterone (T) was found in hyperandrogenism cases (r=0.652;P＜0.000 1).In conclusion,immunologic derangement of Th1/Th2 proportion is found in most PCOS patients,which probably causes by hyperandrogenism.
Keywords：Polycystic ovary syndromeTh1/Th2 cytokinesHyperandrogenismDysgenesis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 456-460 )