Autoimmune mechanisms in coronary heart disease
BI Jiachen
LIU Zhigang
LIU Xiaocheng
Abstract：There are studies showing that coronary heart disease (CHD) is an immune-related chronic inflammation,and autoimmunity plays an important role in the pathogenesis of CHD.Some traditional CHD risk factors are associated with autoimmunity.Patients with autoimmune diseases usually suffer from CHD praecox,which also suggests that CHD is associated with autoimmune.In patients diagnosed with autoimmune diseases,autoantibodies are associated with CHD in various aspects and procedures.Further studies on asymptomatically autoantibody-positive population found that some autoantibodies are closely related with CHD.Meanwhile,cellular immunity also takes part in CHD.It has been suggested that interferon-γ (INF-γ) produced by Th1 cells plays a major role through IFN-γaxis.Therefore,there is a view that CHD is an autoimmune disease.This view will provide a new direction for clinical diagnosis and treatment for CHD.
Keywords：Coronary heart diseaseAutoimmuneHumoral immunityAutoantibodyCellular immunity
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 448-451 )