Effects of compound Cordyceps militaris on ulcerative colitis induced with high-fat diet and dextran sulfate sodium
XU Huilin
LI Hao
PAN Suhua
SHI Weiqing
GUO Haiying
Abstract：This study performed to explore the intervention effect and mechanism of compound cordyceps militaris (CCM) on ulcerative colitis (UC).Animal model of UC was induced with high-fat diet and dextran sulfate sodium (DSS) in C57BL/6J mouse,which were orally administrated with 90,180 and 540 mg· kg-1 · d-1CCM for 8 weeks.The body weights of mice,the levels of occult blood,the levels of tumor necrosis factor-α (TNF-α) and interleukin-1[β (IL-1β) in serum,pathological changes as well as the expression of TNF-α,IkB-α,NF-κBp65 in colonic tissue were observed.Compared with the normal group,the model group showed significant increases in occult blood,serum TNF-α and IL-1β,colon inflammatory infiltration,TNF-α and NF-κBp65 levels,and remarkable decline in IkB-α.Compared with the model group,CCM middle dose group showed obvious relieve in colon inflammatory infiltration,significant reduction in TNF-α,NF-κBp65 expression,body weight,occult blood,remarkable increase in IκB-α expression,and reduction in serum TNF-α,serum IL-1β.Taken together,CCM can inhibit the activation of NF-κB pathway,reduce inflammatory infiltration in colon,and thus prevent UC development.
Keywords：Compound Cordyceps militarisUlcerative colitisNF-κB pathwaysCytokines
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 422-426,432 )